If you have some users who use Lotus cc:Mail, you need at least one server running the cc:Mail message transfer agent (MTA) to connect your Domino system to the cc:Mail system.
If you have some users who use an X.400 mail system, you need at least one Release 4 server running the X.400 MTA to connect your Domino system to the X.400 system.
If you have users in the local Internet domain who are not listed in the Domino Directory, set up a smart host so the Router can forward messages for users in other local mail systems.